There have been recent discoveries which suggest that aging is not due to molecular damage accumulation. It is also not due to any kind of random damage. There are some predictions which talk of a new theory. Mikhail Blagosklonny talks about a drug that is clinically-available. This can slow down aging besides delaying diseases in animals. There is an apparent relationship between diseases and getting old. Still, people are looking for the essence of aging in order to understand and accept any new theory amd read full article.
The common view is that aging is due to the random accumulation of any kind of molecular damage. This can be because of failure of maintenance as repair is costly. This appears as a very logical view that is simple and intuitive. But this theory of damage and repair can lead to predictions that may be incorrect and result in bizarre paradoxes. This theory has a free radical version too that is yet to be confirmed. Hence the theory should always make correct predictions. This is the only way for it to be useful and Mikhail’s lacrosse camp.
Mikhail Blagosklonny presents his view that aging may not be due to the accumulation of molecular damage. Rather, such kind of random accumulation can even be irrelevant to aging. This means that even the cause of molecular damage may not really be that important anymore. Besides, Mikhail Blagosklonny is of the opinion that aging may not even start from day one. This can mean that the period of growth may not really be related to aging. Even when developmental growth is over, there can be growth-signaling pathways that may continue to be there, running on inertia and what Mikhail knows.
He is promoting the hyperfunction theory as several predictions of this theory have been confirmed already. Several signal-transduction pathways that are pro-aging as well as potential anti-aging agents which are targeting them have been identified. There are several existing drugs that have been identified too. These include rapamycin as well as metformin. There would be inhibition of hyperfunction in various downstream processes that are regulated by aging pathways. This is why Mikhail Blagosklonny believes that attenuation of protein synthesis can extend lifespan. There are some anti-hypertension drugs too. These can be used to simultaneously prevent all other kinds of age-related diseases that include cancer. This would include beta-adrenergic inhibitors besides angiotensin II signaling. They are both associated with mTOR signaling. Metformin is an anti-diabetic drug that inhibits the mTOR pathway in an indirect manner. It helps to decrease cancer incidence, besides preventing premature menopause. It has been known to increase lifespan in rats and more information click here.
Rapamycin has been tested on animals too. It has managed to delay the age-related diseases in an animal as well as extend their lifespan too. This is why Mikhail Blagosklonny sees this as an opportunity to extend the health as well as the lifespan of humans too.
He is well respected for his vision and hard work. People listen to what he says. He has done a lot of work in this field and continues to do so.