Clay Siegall leads fight against cancer with next generation of drugs

Clay Siegall is one of the nation’s leading cancer researchers. Through his company, Seattle Genetics, he is leading the development of a new class of drugs that promises to radically enhance the effectiveness of cancer treatment. These drugs, called antibody-drug conjugates, are already making a significant impact on certain forms of cancer. It is hoped that in the coming decades these drugs may eventually lead to a cure.

A molecular Trojan horse

Dr. Siegall first became interested in alternative forms of cancer treatment while attending graduate school. He was shocked by the barbarity of the current treatments, usually involving chemotherapy. These treatments often entailed such horrendous side effects as the loss of hair, violent nausea and even death.

After graduating from George Washington University, Dr. Clay Siegall went to work for the National Cancer Institute, researching a new class of treatments called targeted therapy. After a four-year stint with the National Cancer Institute, he was invited to come on board with Bristol-Myers Squibb as a senior researcher. While there, Dr. Siegall began working on a cutting-edge new line of drugs called antibody drug conjugates, a form of targeted cancer therapy.

Antibody-drug conjugates combined elements of immunology with the extremely potent effects of chemotherapy agents called cytotoxins. The drugs are comprised of an artificial antibody, created in the laboratory for optimal effect, that has been bound or conjugated to a cytotoxic agent. What makes these drugs so remarkable is that, by only targeting the tumor cells, the therapeutic window, the amount of the drug that can be safely given to a patient, can be radically increased. The first great benefit of this treatment is that the patient experiences few or no side effects. The second, is that the amount of cytotoxin that can be safely delivered to the patient can be so great as to completely destroy the tumor with just one course of treatment.

Today, Dr. Siegall is focusing on the continuing development of new forms of antibody drug conjugates. Seattle Genetics currently has eight drugs in the development pipeline and many more licensed to other companies for production. It is hoped that in the near future, this exciting new class of drugs will be approved for a wide variety of cancer types. They may, someday, even lead to a cure.




2 Common Orthopaedic Procedures Done by Greg Finch

Dr. Greg Finch is a specialist in orthopaedic surgery in Queensland, Australia. He speicializes in spinal surgery and other types of surgery. Dr. Greg Finch is especially interested in minimally invasive surgery to prevent accidental injury to the patient.

Dr. Greg Finch currently works at Sunshine Coast Hospital and Health Services. Dr. Greg Finch is also a member of Royal Australian College of Surgeons, the North American Spine Association, and the Society for Minimally Invasive Spine Surgery.

Two common orthopaedic procedures are rotator cuff repair surgery and open shoulder surgery.

A torn rotator cuff can cause a lot of problems. But a simple procedure can help restore it. To repair a torn rotator cuff, a surgeon must attach reattach the torn tendon to the upper arm bone. If the rotator torn is only partially torn, the patient might only need a debridement, or smoothing and trimming the tendon. However, a complete tear in thick parts of the tendon might require a couple of stitches to fully repair.

Open shoulder surgery is very important because the shoulder is very important. It’s actually the most flexible joint in the body. But unfortunately, that also means it is easily damaged. To fix and heal severe damage, open shoulder surgery might be necessary. This could mean arthroscopy, which is when small surgical incisions are made and a camera is directed inside the shoulder. The images are projected on a large screen so the surgeon can direct the small surgical instruments without opening up the shoulder too much. This method results in less pain than complete open surgery and a shorter recovery time.

These are two of many common orthopaedic procedures. While surgery is usually a last resort, sometimes it is necessary. And for that, you need a knowledgeable surgeon you trust, and that surgeon can be Dr. Greg Finch.


How Construcap Is A Leader In The Brazilian Construction Industry

Construcap is one of the ten largest construction companies in Brazil. The company was founded in 1944 and now works on construction projects throughout the country. The types of construction projects that Construcap works on are in both the public and private sectors and include industrial, commercial, roads, airports, ports, rail, and infrastructure. It is headquartered in São Paulo.

Among recent projects that Construcap has started to work on, a consortium that is is part of will be finishing the São Francisco River transposition project. The contract is worth R $442 million and will complete the last part that enables the city of Ceará to obtain water from Veho Chico. This is an important project as the city has been in desperate need of an additional source of water for over a decade.

Construcap also completed the Arena Mineirão which was only the second arena in the world to be awarded the Leed Platinum Certification Seal. In order to earn this seal, Construcap has to build it to be sustainable and environmentally friendly. The stadium features a state of the art air circulation system that reduces the consumption of air conditioning by over 40%. It also collects all of the rain that falls on the building into enormous rain barrels that are used to water the field and provide water for toilets and urinals. The solar panels that Construcap installed can collect enough power to provide electricity to over 1,200 homes. Also, 90% of the waste that is generated at games is collected and recycled due to the waste system that Construcap installed into the facility.

In order to be able to do projects like Arena Mineirão, Construcap provides its engineers and other workers with lots of opportunities to learn the latest construction techniques and technologies. As Construcap is also socially responsible before a construction project is started the company sends a team of instructors to the area in order to train people to do jobs like painting and masonry. These workers are also provided with the tools and clothing they need to do the job. Construcap also emphasizes hiring women in a male dominated industry.

Liquid Velvetines Definitely Deliver

Today’s beauty trends are defined by contradictions; looks must be both bold and practical, feminine yet strong, reliable… but ready to ride the wave of exciting emerging trends. What’s a girl (or boy!) to do?


For your lips, at least, Lime Crime has the solution. Founded by CEO and owner Doe Deere in 2008, the company was born out of a desire to design highly pigmented, gorgeously rich lipsticks for trendsetters looking to add an extreme pop of color to their pouts. Luckily for conscientious consumers, the brand also places a huge emphasis on keeping their products cruelty-free: both PETA and Leaping Bunny certify all their products 100% Vegan.


Doe Deere’s original line of lipsticks, Unicorn Lipsticks, first launched in 2009 and changed the market forever. One of the very first beauty brands launched digitally, the brand’s dramatic hues became a cult sensation on the Internet, and in 2012 the company raised the bar again with the launch of their Velvetines.


Velvetines are liquid lipsticks, designed to apply with impeccable ease and last all day. Lime Crime offers two versions of its famous Velvetine line, both classic matte and the new metallic option. For the individual who just can’t choose one color, they also offer Velve-tins, miniature Velvetine box sets that include three mini Velvetine colors, all in one keepsake package!


Their sumptuous, velvety finish defines the original Velvetine Line. Velvetines are ultra-lightweight despite their impressive visual punch, and can transform a look from glum to glam in moments. The finish is opaque and inarguably opulent, not to mention smudge-proof. The company’s metallic Velvetines, also called “Perlees,” combine the best of two worlds, marrying all the pros of their classic Velvetine line with all the excitement of a metallic finish. Perlees offer full-coverage and a soft sheen, all while protecting your lips with moisturizers and rosemary extract.


Whether you prefer the classic matte or the psychedelic metallic, Lime Crime has the hue for you! Liquid lips are in, and these innovators are at the head of the race.


OSI Group’s Recent Acquisitions

OSI Group is an Aurora-based packed-food processing company which was started in 1909 by a German immigrant by the name Otto Kolschowsky.

Initially, it was a family meat-processing market, but it has since expanded to become one of the best food processing companies in the world. OSI group has made some purchases over the recent past, therefore, broadening their presence in the world. Some of the notable acquisitions that OSI group has made includes: Baho Food, Tyson Foods Plant, and Flagship Europe.

Baho Food
Baho Food is a Dutch manufacturer of snacks, deli meat, and convenience foods. In trying to broaden their presence in Europe, OSI Group purchased the company though the financial terms of that transaction were not disclosed. With Baho as part of the OSI Group, the processing strength was boosted, and the capabilities of serving their customers’ needs improved. Baho Food has several processing plants based both in Netherlands and Germany and it serves customers across 18 European countries.

Tyson Foods Plant
This processing plant is based in Chicago and was purchased by OSI Group for $7.4 million. With this processing plant, the capabilities of meeting the evolving needs of customers have been enhanced. Before being purchased by OSI Group, Tyson Foods used to prepare meals for the hospitality industry. These meals included Chicken Cordon, sauces, soups, omelets, crepes, meatballs and tempura chicken.

Flagship Europe
Flagship Europe is a supplying company that operates across the United Kingdom with it main supplies being sauces and frozen poultry. After being purchased by OSI Group, the company broadened their supply to include dips, mayonnaise, marinades and sandwich fillings. This acquisition was a welcome idea since it has boosted the progressive development of the company.

Construcap Real Estate is Making an Impact

When you are looking to make a major real estate decision, it pays off to have some expert advice on your side. Construcap is a company that has helped millions of people in Brazil get to the next level with their real estate purchases. Over time, this is a company that has proven they have the best interests of their customers in mind. If you want to buy or sell a property, this is the company to work with. Construcap will continue to invest in the future of Brazil with their business.


Real Estate


There are few industries as dynamic as the real estate industry. Over the past couple of years, there are a lot of people who have done a great job of helping others get to the next level. However, few companies have done as much as Construcap has. If you want to take your investing to a new level, this is the company to work with. They have always invested back into their customers, and they are prepared to take things to a new level with all of their recent investments.


Future Plans


If you want to buy or sell a property, work with Construcap on the deal. They are a company that is committed to helping customers any way that they can. In addition, they have a track record of success in helping others get to a new level. Buying or selling a home is a major financial decision, and you need to make sure you have quality advice on your side during the process. A lot of people are excited about what the future holds with all of the economic growth forecasted in Brazil.


Why Jason Halpern is a Dominant Force in the Real Estate and Philanthropy Arenas

Property Developer: Jason Halpern

Jason Halpern is a serial real estate investor and developer from Brooklyn, New York. Halpern is the founder and president of JMH Development. He comes from a generation of property developers and has been groomed to handle real estate business. His family has been in this line of work for close to five decades. Before launching JMH Development, Halpern worked at his father’s firm, a company responsible for construction and development of various apartments in Westchester County as well as New York City. It was while working for the family business that he developed interest and passion for property development.

JMH Development

Jason Halpern in Production

Halpern has since grown into a visionary entrepreneur that employs his experience and foresight during acquisition and renovation of properties, including some historically landmarked structures. Halpern established JMH Development a couple of years ago. This company owns various commercial and residential businesses across the United States. JMH Development also specializes in the development of luxury properties in Brooklyn and Williamsburg. As the head of the company, Halpern emphasizes the use of innovative approaches when refurbishing these prestigious properties. Some of the firms’ major achievements include renovation of properties in 340 luxury rentals as well as 184 Kent Avenue.


Jason in Modeling Industry

Halpern has a tendency of creating a rapport with the county officials, and this enables him to acquire significant historic buildings and rehabilitate them. He has continued to build his company with values of integrity and respect to the community. His business is committed to enhancing innovativeness and social responsibility. JMH Development most recent projects include the development of Townhouses in Cobble Hill. Under Halpern’s management, his firm was presented with the 2011 Building Brooklyn Award and was made one of the stakeholders in the National Historic Register. Halpern is open-minded and is always ready to assist clients in need of real estate services.

Jason Halpern’s philanthropic involvement

With His Wife

Halpern is dedicated to helping out the less fortunate in the society. He allocates his part of his personal time to charitable endeavors. Since 2015, he has been involved in charity activities to fund water projects in East African countries. This water project receives funds amounting to $20,000 from JMH Development. Halpern also supports the Relief Society of Splash and Tigray through his firm. He also supports health causes through donating to the Westchester Medical Center, a well-equipped level 1 trauma facility in the United States. This health center provides services such as reattachment of severed limbs, open-heart surgery, and complex emergency neurosurgery. Through donations, this medical center has been able to launch a department to care for burn victims with severe internal injuries. Additionally, Halpern supports causes and involving children and women in the society.

Reminding IsraeliAmericans to be Proud of Who They Are and Where They’ve Been

Adam Milestien’s parents were immigrants to Israel when they met. His mother was from Mexico and his father from Argentina. They taught him to work hard and be proud of where he came from. He served during the Yum Kippur War and then enrolled in college, graduating with a bachelor’s degree in business and economics. Throughout this time he also married Gila Elgrably and helped his father grow their real-estate business and in 1981 they moved to the United States so that Adam Milestien could persue a master’s degree from the University of Southern California (USC).

He continued with his passion in real-estate but also began to realize his true calling was in philanthropy. In response to this passion, Adam and Gila have created the Milestien Foundation that does various charity work including supporting their cultural background, reminding Israel-Americans that they can be proud of who they are and where they came from.

One event that the Milestien Foundation has created is the “Inspired by Israel” contest. There were eighty contestants and ten of them will go on to have their presentation given in front of an elite panel of judges including Gila Milestien, Tribe Media Journalist David Suissa, and StandWithUs Executive Director Michael Dickson. The contest will provide over twenty thousand dollars in prizes, including an eight thousand dollar grand prize. Last year, the program provided over 500,000 views to their cause and the winning theme was “Superman’s Got Nothing on Israel.”

With each program’s success we are one step closer as a world united.

Dr. Jennifer Walden: Rejuvenating Confidence Through Surgery

Dr. Jennifer Walden is a plastic surgeon based out of Austin, Texas. She specializes in Venus Freeze, Cosmetic Breast Enhancement, Facials and Rhinoplasty. Dr. Walden also works for the non-profit organization, “Austin Smiles”, performing surgery in third world countries for children born with cleft lips and palates. She has been practicing plastic surgery for about 12 years and is considered one of the best in her field. Dr. Walden has been featured as an expert commentator on cosmetic surgery by ABC News, Fox News and Dr. 90210.

Dr. Jennifer Walden earned her undergraduate degree in Biology from the University of Texas. She completed medical school at the University of Texas Medical Branch, graduating salutatorian of her class. Dr. Walden would then earn a fellowship in aesthetic surgeryq at the Manhattan Eye, Ear and Throat Hospital. While in New York, Dr. Walden participated in clinical trials that led to the reintroduction of silicone breast implants. In 2011, she would return to her hometown of Austin Texas where she opened up a private practice in Westlake Hills.

Dr. Jennifer Walden’s practice philosophy is ” to promote health and well-being through comprehensive and personalized approach to rejuvenative or reconstructive surgery.” Dr. Walden has emphasized that her mission is not to replicate the male ideal archetype of a “Barbie-doll” body. Rather, it is to rejuvenate their self-confidence and quality of life. She believes that being a female doctor makes her more empathetic than her male counterparts especially when it comes to the body changes that occur as a result of pregnancy. Dr. Walden has had numerous article published in medical journals and is the Co-Author of Aesthetic Plastic Surgery Textbook.


Understanding John Goullet Participation in the Tech Industry

With the growing, changing and advancing of the tech industry, numerous people have decided to venture the industry in various ways. John Goullet is one individual who has ventured into the tech sector with no fear and determination to bring about change. He is an IT entrepreneur who has gained respect over the years from his fellow workers and people worldwide. He has been responsible for the creation of various industries that have gradually grown to become the best in the industry. Mr. John’s career begun as an IT consultant before venturing in IT staffing. Nobody would have ever imagined that John would be in a position of building companies that people go to look for tech solutions. Some of the firms that have helped in raising his social standards include the Info Technologies. Info Technologies majorly focuses on providing IT staffing solutions to people and other corporations especially the Fortune 500 Companies. John aimed at opening a business that will be in a position of understanding the It Staffing problems available in today world and tries to find solutions to these issues. After Info Technologies had grown and developed, it merged with Diversant Inc to later form Diversant LLC.
Diversant LLC has become a firm that is able to gain the clients trust as is available to offer services required by the customer. With this, it becomes easy for the company to establish a healthy relationship with the customer through providing quality services. Some of the major services it offers include direct hiring, strengthening IT employees and several services. One thing that has made the firm outstanding is the fact that it engages its customers in various aspects which make the clients feel incorporated into the company’s success. It is well known that through establishing healthy relationships with your customers, your business is bound to develop at a higher rate.
New technology which is continually advancing has led to the lack of experts who can be in a position of keeping up with the tech, and this is what John tries to solve. He wants to open industries that will be experts who are highly qualified to address any tech problem. With such an idea, John believes that with time every tech problem will be handled by his numerous firms.